Oxford-GSK-Imanova Striatal Connectivity Atlas


Figure 1: The striatum-con-prob-thr50 atlas
Figure 1: The striatum-con-prob-thr50 atlas


Probabilistic connectivity striatal atlas segmented into 7 sub-regions according to cortical-striatal anatomical connections (7 cortical targets: limbic, executive, rostral-motor, caudal-motor, parietal, occipital and temporal cortical zones). Each striatal voxel is classified (labeled) according to the cortical region that has the highest probability of connection. These probabilities are defined as the number of subjects with a within-subject-connection-probability (between the striatal voxel and the cortical target) higher than 25% or 50%, divided by the total number of subjects. Figure 2 shows the striatum-con-label-thr50-7sub atlas.

Figure 2. Striatum-con-label-thr50-7sub atlas
Figure 2. Striatum-con-label-thr50-3sub and Striatum-con-label-thr50-7sub atlas


Construction of the connectivity atlases

To obtain the connectivity-based functional striatal sub-territories, DWI data and probabilistic tractography algorithms (Behrens et al. 2003) were employed. In total 26 healthy human volunteers were scanned and to achieve the connectivity-base subdivision in each subject, a two-step procedure was applied (figure 3): Phase I: the projections from the four brain lobes (frontal, parietal, occipital, temporal) to the striatum were calculated and the striatal areas associated with each lobe were established; Phase II: The frontal lobe was subdivided into four anatomical ROIs, each associated with a particular functional specialization (limbic, executive, rostral motor and caudal motor), and projections between these anatomical ROIs and the striatal area associated with the frontal lobe was estimated.

Figure 3. Methods overview
Figure 3. Methods overview

Cortical Targets





Parietal, occipital and temporal cortical lobes were obtained from the Harvard-Oxford cortical atlas (figure 4).

Figure 4: Cortical targets
Figure 4: Cortical targets

Detailed information about the construction of the connectivity atlas can be found in: Tziortzi et al. Connectivity-based functional analysis of dopamine release in the striatum using DWI-MRI and Positron Emission Tomography


Atlases/striatumconn (last edited 19:08:15 25-02-2013 by MarkJenkinson)